CD BioGlyco, a leader in glycosylation characterization, recently developed a comprehensive glycoproteomics platform to provide its customers worldwide with the characterization of glycosylation in protein drugs.
Glycoproteins, such as glycosyltransferases, glycosidases, erythropoietin, and cytokines, make up the majority of biotherapeutic products. Although the drugs themselves are complicated, it is urgent to develop techniques to characterize glycosylation in order to better evaluate their effects.
One of the most significant post-translational modifications during protein characterization is glycosylation. It affects the drug's biological activity, serum half-life, stability, and immunogenicity, which alters how the drug interacts with the patient's cells. This is a crucial quality attribute of therapeutic protein drugs. Therefore, accurate characterization of glycosylation in biopharmaceutical processes requires the use of quantitative analytical methods.
Given the significance of glycosylation in protein drugs, CD BioGlyco offers clients thorough services for characterization of glycosylation in protein drugs.
Identification and quantification of various monosaccharides, including fucose, mannose, and galactose.
Identification and quantification of sialic acid, including N-acetylneuraminic acid and N-glycolneuraminic acid.
Overall analysis of oligosaccharides
LC-MS and MALDI/TOF-MS are used to analyze N-glycans and O-glycans in protein drugs.
Glycosylation site analysis
LC-MS detects hydrolyzed digests of specific proteins and then analyzes the glycans at each glycosylation site by collecting isolated glycopeptides.
Site occupancy analysis
“For many years, we have been dedicated to research in the field of glycosylation, offering our clients high-quality, economical, and hassle-free glycosylation characterization services.” said Anna, one of the representative speakers from CD BioGlyco.
According to Anna, they also provide characterization services of antibody drug, including glycan analysis, glycopeptide analysis and glycoprotein analysis; and intact protein and subunit level analysis, intact glycopeptides analysis, glycan analysis, and sialic acid analysis services.
To know more detailed information about the characterization services of glycosylation in protein drugs provided by CD BioGlyco, please visit https://www.bioglyco.com/characterization-of-glycosylation-in-protein-dr...