People overeat and become overweight for a variety of reasons. The fact that tasty, high-calorie foods are available almost anywhere, anytime, doesn't help. Recently, researchers at the Buck Institute for Research on Aging determined for the first time why certain chemicals in cooked or processed foods, known as advanced glycation end products (AGEs), increase hunger and seriously challenge people's fixation on these foods.
A New Theory of Tumor Drug Delivery
People overeat and become overweight for a variety of reasons. The fact that tasty, high-calorie foods are available almost anywhere, anytime, doesn't help. Recently, researchers at the Buck Institute for Research on Aging determined for the first time why certain chemicals in cooked or processed foods, known as advanced glycation end products (AGEs), increase hunger and seriously challenge people's fixation on these foods.
Transvascular penetration of therapeutic nanoparticles (NPs) into the tumor mesenchymal space is critical for the treatment of solid tumors. Endothelial cells form the inner layer of blood vessels and are the main barrier regulating the entry of fluids, macromolecules, and immune cells into the mesenchymal space. Nanoparticles can bypass the endothelial barrier through active transendothelial or passive parietal endothelial transport pathways.
The most important thing to remember is that a typical vaccine trains the body's immune system to recognize foreign invaders, such as viruses and bacteria, as enemies and then attack them.
This clearing of immune memory is obviously undesirable for infectious diseases but could stop autoimmune responses such as those seen in multiple sclerosis, type 1 diabetes, rheumatoid arthritis, and Crohn's disease, in which the immune system attacks the body's healthy tissues.
Monkeypox, a zoonotic disease, was first discovered in monkeys used for research in 1958 and is spread primarily among animals. The first human case of monkeypox was found in the Democratic Republic of Congo (DRC) in 1970, and since then, monkeypox has been endemic to a number of African countries, including Nigeria, the DRC, and the Central African Republic. Monkeypox cases outside of Africa are usually contracted as a result of traveling to Africa.
On October 2, 2023, the Nobel Prize in Physiology or Medicine was awarded to two of the founders of mRNA technology—Katalin Karikó and Drew Weissman.
Ebola virus (EBOV), a virulent infectious virus, was first discovered in 1976 in the Ebola River region of southern Sudan and the Democratic Republic of the Congo (DRC), causing widespread concern and attention in the medical community. The Ebola virus can cause Ebola hemorrhagic fever in humans and other primates, and its cause, Ebola hemorrhagic fever (EBHF), is the world's most lethal virus today, with a mortality rate of between 50% and 90% of those infected.
In the intricate world of genetics, the multitude of genes present in humans and animals like mice is not the sole determinant of cellular health and function. Rather, the crux lies in the intricate dance of gene activation and deactivation. As science delves into the realms of aging, living conditions, behaviors, and environmental influences, it uncovers a fascinating phenomenon known as epigenetics, which has garnered significant attention in contemporary research.
Undoubtedly, proteolysis targeting chimera (PROTAC) technology stands as a revolutionary approach in drug development. By leveraging the ubiquitin-proteasome system to degrade target proteins, this technology has redefined the landscape of drug discovery and treatment. Despite its remarkable strides, PROTAC encounters a challenge in the form of non-tumor toxicity in healthy cells. This issue hinders the clinical feasibility of targeted cancer therapies.
