creativebiolabs's blog

Over the past 30 years, traditional monoclonal antibodies have occupied an important position in the development of therapeutic biomolecule drugs. In 1993, Belgian scientists published a paper in Nature, discovering for the first time in the alpaca body a naturally occurring variable region of heavy-chain antibody (HcAb) lacking light chain with a molecular weight of only 15 kDa, which is 1/10 of the molecular weight of traditional antibodies. It is also the smallest known natural antibody, and it is named a single domain antibody (sdAb).

No organism on Earth is immune to threats, including bacteria. A class of predatory viruses called phages is one of bacteria's worst enemies, invading the bacterium's interior to replicate and ultimately causing it to lyse. And while bacteria have evolved a range of strategies to combat phage invasions, how they detect these invaders in the first place has been a mystery.

Recently, Luciano Marraffini's team at Rockefeller University published a research paper in the journal Nature titled "Bacterial cGAS senses a viral RNA to initiate immunity".

The human body carries a far greater number of symbiotic microorganisms than we can imagine. Cells are the basic units that make up the human body, and the total number of cells in an adult is on the order of tens of trillions. However, the gut flora, which is symbiotic with the human intestinal tract, is ten times the number of cells in the body, and its composition is quite complex, with roughly 500 to 1,000 different species of bacteria in each individual's body.

The maintenance of homeostasis by cells and organisms under stressful conditions is achieved through the activation of a highly conserved cellular stress response. Adaptive stress responses respond to stimuli and restore cellular homeostasis through a network of signaling mechanisms, but sustained and/or excessive stress responses can be harmful and even lead to apoptosis. Cellular stress usually affects multiple organelles simultaneously, triggering multiple stress responses.

The maintenance of homeostasis by cells and organisms under stressful conditions is achieved through the activation of a highly conserved cellular stress response. Adaptive stress responses respond to stimuli and restore cellular homeostasis through a network of signaling mechanisms, but sustained and/or excessive stress responses can be harmful and even lead to apoptosis. Cellular stress usually affects multiple organelles simultaneously, triggering multiple stress responses.

Cholesterol consists of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). High levels of LDL-C cause cholesterol to be deposited on the walls of blood vessels, which can lead to cardiovascular disease. HDL-C is also known as "good cholesterol" because it protects blood vessels, prevents the deposition of LDL-C on blood vessel walls, and reduces the risk of cardiovascular disease.

The neurodegenerative disease therapeutics market is undergoing a transformation. The segment is estimated to reach $216.6 billion by 2026.

Previously, an obese person had only one option to achieve rapid and significant weight loss—bariatric surgery.
And the advent of the GLP-1 class drug, simethicone, has made it possible for people to achieve approximately 15% weight loss with the drug. And tilprotectin achieved 22.5% weight loss in a phase 3 clinical trial, a figure that is close to the effectiveness of surgical weight loss.

Lyme disease, a natural epidemic caused by Borrelia burgdorferi infection, is usually transmitted to humans by the bite of a blacklegged tick and can cause fever, headache, fatigue, and rash. If left untreated, the infection can spread to the joints, heart, and nervous system.

Since its discovery in 1979, the p53 gene has been one of the focal points of oncology research. A search in the PubMed database using p53 as a keyword will find more than 100,000 articles.