Europe PDX models Market which was USD 48002.80 thousand in 2022, is expected to reach USD 162882.33 thousand by 2030, at a CAGR of 16.5% during the forecast period 2023 to 2030.
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Pancreatic cancer (PC) remains a highly lethal cancer, which still requires profound clinical and preclinical research. The predictive power of patient-derived xenograft (PDX) model determines that it will become an important tool for preclinical and clinical research. PDX is not only widely used in preclinical studies of PC drugs, but also can be used to predict the result of human clinical trials. The PDX model and the corresponding patients’ co-clinical trial can quickly obtain the drug response, optimize the combination, explore drug resistance mechanisms, and screen for biomarkers. Meanwhile, PDX can be used for personalized medicine as patient’s avatar model. With the development of novel PDX models: patient-derived orthotopic xenografts (PDOX) model, humanized PDX model and CTC-derived PDX model, cooperation of various research teams is needed to build PDX encyclopedia of PC.
Type
• Mice Models
• Rat Models
Tumor Type
• Gastrointestinal Tumor Models
• Lung Tumor Models
• Haematological Tumor Models
• Gynecological Tumor Models
• Respiratory Tumor Models
• Urological Tumor Models
• Others
Application
• Preclinical Drug Development
• Precision Medicine
• Co-Clinical Trials
• Basic Cancer Research
• Biomarker Analysis
• Oncology Research
Technique
• Heterotopic Implantation
• Orthotropic Implantation
End User
• Academic and Research Organizations
• Contract Research Organizations
• Pharmaceutical and Biotechnological Companies
• Others
The generation of patient-derived xenograft (PDX) models involves a selection bottleneck imposed by tumour engraftment, and subsequent propagation influences the evolutionary trajectories of cancer cells; therefore, these models can be used to investigate tumour clonal composition and competition during spontaneous tumour progression and under the selective pressure of treatment. Work in which PDX models were studied at the moment of maximal tumour shrinkage during exposure to a given therapy has provided insights into lineage-specific phenotypic adaptations, which underlie the acquisition of drug tolerance and are responsible for sustaining residual disease. The substitution of human stromal cells by mouse stromal cells that occurs after tumour implantation has enabled the identification of transcriptional signatures related to either cancer or stromal cells with predictive and prognostic value.Large collections of PDX models have contributed to the discovery and validation of novel biomarkers of response to treatment and have aided the design of new therapeutic options, some of which have entered the clinic.
Highlight of Table of Content:
Chapter 1: Market overview
Chapter 2: Europe PDX models Market Analysis
Chapter 3: Regional analysis of the Europe PDX models Market
Chapter 4: Market segmentation based on types and applications
Chapter 5: Revenue analysis based on types and applications
Chapter 6: Market share
Chapter 7: Competitive Landscape
Chapter 8: Drivers, Restraints, Challenges, and Opportunities
Chapter 9: Gross Margin and Price Analysis
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Some of the major players operating in the patient derived xenograft (PDX) models market are:
• Crown Bioscience Inc. (U.S.)
• THE JACKSON LABORATORY (U.S.)
• Champions Oncology, Inc. (U.S.)
• Charles River Laboratories (U.S.)
• Wuxi AppTec (China)
• Oncodesign (Canada)
• Aragen Bioscience (India)
• Biocytogen (U.S.)
• Bioduro (U.S.)
• Creative Animodel (U.S.)
• Covance Inc. (U.S.)
• EPO Berlin-Buch GmbH (Germany)
• EUROPDX. (Belgium)
• Explora BioLabs (U.S.)
• Hera BioLabs (U.S.)
• Horizon discovery Ltd. (U.K.)
Profound Questions Answered in this Report:
• What is the growth rate of various stages in the value chain of the industry?
• Which region has the highest growth rate and size of the emerging market by value in 2022?
• Who are the competitive players in Europe PDX models Market?
• Which region has the largest share and degree of competition in the industry?
• What is the CAGR of the market during the forecast period 2023 to 2030?
• Which region is expected to hold the highest market share for the market?
• What is the main driver of the Global Patient Derived Xenograft (PDX) Models Market?
• What is sales volume, revenue, and price analysis of top players of the market?
• What are the market opportunities and threats faced by the vendors in the industry?
• What has been the impact of COVID-19 on the Europe PDX models Market?
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