In the area of psychotropic drugs, tryptamines are known to be a broad class of classical or serotonergic hallucinogens. These drugs are capable of producing profound changes in sensory perception, mood and thought in humans and act primarily as agonists of the 5-HT2A receptor. Well-known tryptamines such as psilocybin contained in Aztec sacred mushrooms and N,N-dimethyltryptamine (DMT), present in South American psychoactive beverage ayahuasca, have been restrictedly used since ancient times in sociocultural and ritual contexts.
However, with the discovery of hallucinogenic properties of lysergic acid diethylamide (LSD) in mid-1900s, tryptamines began to be used recreationally among young people. More recently, new synthetically produced tryptamine hallucinogens, such as alpha-methyltryptamine (AMT), 5-methoxy-N,N-dimethyltryptamine (crazy train bath salts) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), emerged in the recreational drug market, which have been claimed as the next-generation designer drugs to replace LSD ('legal' alternatives to LSD).
Tryptamine and its derivatives that have been reported as NPS are indolealkylamine molecules. While some naturally occuring tryptamines are neurotransmitters (e.g. serotonin, melatonin and bufotenin), most are psychoactive hallucinogens found in plants, fungi and animals (e.g. N,N-dimethyltryptamine (DMT) psilocybin, and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) [1-3].
The use of the naturally occurring psilocybin, became widespread in the late 1950s in the United States, whereas synthetic tryptamines appeared on illicit drug markets only throughout the 1990s. Recently, a group of synthetic tryptamines that are derived from DMT and other naturally occurring tryptamines have been reported as NPS, including 5-MeO-DMT, 5-MeO-DPT, AMT, 4-AcO-DMT and 4-AcODiPT
DMT, etryptamine, N,N-diethyltryptamine (DET), Psilocin and psilocybin, are the only tryptamines under international control (listed in Schedule I of the 1971 Convention), while some others are controlled at the national level in several countries.
Description
Street names for some tryptamines include ‘Foxy-Methoxy’ (5-MeO-DIPT); ‘alpha-O’, ‘alpha’ and ‘O-DMS’ (5-MeO-AMT); o-desmethyltramadol vendor (5-MeO-DMT). Natural tryptamines are available in preparations of dried or brewed mushrooms, while tryptamine derivatives are sold in capsule, tablet, powder or liquid form. Tryptamines are generally swallowed, sniffed, smoked or injected.
Tryptamines act predominantly as hallucinogens. Classic hallucinogens (psychedelics) mediate specific serotonin-receptor activities and produce hallucinations. Substances in these group mimic the effects of traditional drugs such as 2C-B, LSD and DMT but may also possess residual stimulant activity.
What foods contain tryptamine?
Tryptamine, as well as cadaverine, phenylethylamine and putrescine are biogenic amines found in a variety of foods and beverages, especially in protein-rich (fish and meat), and in fermented foods (cheese, salami); in beverages (wine, beer), fruits, vegetables and citrus juices, chocolates, fish sauces, and sausages
bath salts
research chemicals
o-dsmt
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