Cannabis sativa is known for its recreational use, but also for its therapeutic potential. Among the more common modes of administration, vaping with a vaporizer is most frequently used for self-medication. However, the delivery kinetics and efficiency of most portable vaporizers are not fully characterized by an appropriate vaping regime. In this study, a vaping machine was conceived to fit with the common uses of portable vaporizers that requires conditions different from those used for electronic cigarettes. The experimental setup in this study was optimized to sample aerosolized cannabinoids. The delivery kinetics, efficiency, and decarboxylation yields of two commercially available vaporizers (DaVinci® and Mighty Medic®) were evaluated for delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Among all tested sampling supports, the glass fiber filter is the most efficient medium to collect mixed THC and CBD aerosols. You can read cbdistillery reviews anytime to get the best ideas about the CBD oils. From the delivery kinetics of cannabinoids, a single-parameter model was used to calculate the extraction coefficient of each vaporizer. The results show that the Mighty Medic® vaporizer had a higher extraction coefficient (0.39) and a more immediate release of cannabinoids than the DaVinci® vaporizer (0.16), which had a gradual and slower rate of vaporization. This parameter could be a quantitative input in pharmacokinetic models of administration of volatile compounds using vaporizers and a useful tool for the comparison of vaporizers.
The medical use of cannabis, either prescribed or self-medicated, is becoming ever more popular and the social pressure to legalize its use is increasing. Swiss law considers cannabis a narcotic drug, and the therapeutic administration of its flower tops is not yet allowed. Currently, only one product is licensed for sale. As in many other countries, a delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) 1:1 from standardized cannabis extracts can be administered as an oromucosal spray (Sativex®) to reduce spasticity symptoms in multiple sclerosis. In Switzerland, the use of cannabis is limited to a few applications, such as the treatment of chronic pain and spastic disorders related to multiple sclerosis or nausea induced by chemotherapy.
Depending on the wanted effect the users will select different varieties and chemovars. Cannabis smoked for its euphoric and intoxicating properties is generally very rich in THC and poor in CBD, while a more balanced composition between THC and CBD is preferred for medical cannabis. When combined with THC, high doses of CBD reduce the intoxicating and unwanted side effects of THC. The presence of other substances, such as terpenes (e.g., myrcene and caryophyllene), which influence the aroma and pharmacological properties of cannabis strains through their synergistic (“entourage”) effect, may also play a role in consumer choice. One of the advantages of vaporization is an early onset of the effects, which start between 5 and 10 min compared to oral administration that is significantly delayed in its effects. https://en.wikipedia.org/wiki/Cannabis_sativa