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Tapentadol is a prescription medication used to treat moderate to severe pain. It belongs to a class of drugs known as opioid analgesics. Tapentadol works by binding to mu-opioid receptors in the brain and spinal cord, where it acts as an agonist (activator) of these receptors. It also inhibits the reuptake of the neurotransmitter norepinephrine. These mechanisms help to reduce the perception of pain and increase pain tolerance. Tapentadol is primarily indicated for the relief of moderate to severe acute pain, such as that experienced after surgery or due to injury. It may also be used to manage chronic pain in certain situations where other treatments have been inadequate.

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