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  • It was found that naltrexone and bupropion combined, that could be marketed down the road as Contrave, give better weight loss results than diet and exercise alone.

    Using two separate drugs to shed weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err assisting caution and let the FDA do its job and demand some investigation be done so the public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on the medications.

    Researchers found out that participants taking this drug for the year, dropped excess weight within 4 weeks and have kept the extra weight off throughout the 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, which may make them more efficient and safer.

    Combo-pilling is the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular will be the fact that as of right now there aren't any long term prescription weightloss pills that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures can be a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug could also raise blood pressure levels and pulse rate, and shouldn't be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

    "This will be the first drug I'm alert to that targets the two appetite and reward centres inside the brain," he said.