The thyroid cells are protein-secreting cells and Thyroid Support Review one of their major products is thyroglobulin. Thyroglobulin is a large glycoprotein molecule with a molecular weight of around 335,000. Each molecule of thyroglobulin contains around 70 amino acids called tyrosine, the major substrate that combines with iodine to form the thyroid hormones. Basically, the thyroid hormones are formed inside the thyroglobulin.
The first essential step in the formation of thyroid hormone is the oxidation of iodide ions to nascent iodine capable of combining with tyrosine. This process is promoted by the enzyme peroxidase and its accompanying hydrogen peroxide.
The next step is the organification of iodine or the binding of iodine with the thyroglobulin molecule. Even in its oxidized form, iodine binds quite slowly to tyrosine. In the thyroid cell, however, iodine is associated with aniodinase enzyme which speeds up the organification to a matter of seconds or minutes.
- hadrielsam's blog
- Log in or register to post comments