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Tramadol and acetaminophen serve as pain relievers, but they differ in their nature. Tramadol is classified as a narcotic pain reliever, whereas acetaminophen is an over-the-counter option. On the other hand, nonsteroidal anti-inflammatory drugs (NSAIDs) belong to a drug class that effectively alleviates pain, inflammation, and fever. These drugs can be obtained without a prescription or with one. NSAIDs present a viable alternative to tramadol or acetaminophen for pain relief, as they offer similar efficacy without the accompanying side effects of narcotics.