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Opioid analgesics such as tramadol are commonly used to treat moderate to severe pain. As it is an opioid, a type of analgesic that works on the central nervous system, tramadol attaches itself to brain and spinal kord opioid receptors. This changes the way the body interprets and reacts to pain. Cervical spondylitis, back pain, joint pain, and pain management after surgery are all indications Tramadol is frequently recommended for use. Quite apart from its anodyne properties, tramadol also exerts particular actions by interfering with the uptake in its own pharmacological action on serotonin and norepinephrine. This may enhance its anodyne efficacy.

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