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Tapentadol is a centrally acting opioid analgesic used for the management of moderate to severe acute pain. It acts as both a mu-opioid receptor agonist and a norepinephrine reuptake inhibitor. This dual mechanism of action provides pain relief through two distinct pathways.

Tapentadol was developed as an alternative to other opioids like morphine, oxycodone, and tramadol. It is thought to have a reduced risk of certain side effects common with traditional opioids, such as respiratory depression and gastrointestinal disturbances.

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