It is a very hard skill and requires a complete lot of Cheap RS Gold time, effort and if you do not have Runescape 2 money to start with. Often the potions which sell very well are prayer, fishing, quickness, ranged, anti-fire and Relatively sets (Super Attack, Relatively Strength and Super Defence) and the rest are a little harder to sell.
At 20 Herblore in Runescape 3, there is a herb you can distinguish called Ranarr Weed. That is a very popular, in-demand herb. If IDed, these herbs easily sell for 3k to 4k each. Once you reach 34 herblore, you can make one of the most common potions is the Prayer Thérapeutique. Prayer potions in Runescape 2 sell for five carat each, so you could obtain ranarrs, and sell the potions at 1k to 2k profit then.
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