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Tapentadol is a centrally acting analgesic medication used for the management of moderate to severe pain. It works by binding to mu-opioid receptors in the central nervous system and inhibiting the reuptake of norepinephrine. This dual mechanism of action distinguishes tapentadol from traditional opioids, as it provides analgesia while potentially reducing the risk of respiratory depression and constipation.
It is also used for the management of chronic pain conditions such as neuropathic pain, including diabetic peripheral neuropathy, postherpetic neuralgia (nerve pain following shingles), and other neuropathic pain syndromes.
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