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Profacgen, a biotechnology company that provides custom protein services in the biological sciences, recently enhanced its structure-based virtual screeningservice for scientists in the field of drug discovery and lead optimization.
On November 3, Cancer Cell published online a research paper entitled "FOXA2 lineage plasticity drives and KIT pathway activation in neuroendocrine prostate cancer" by Gao Dong's research group at the Center for Excellent Innovation in Molecular Cell Science, Chinese Academy of Sciences. This study reveals the key role of FOXA2 in regulating the transition of prostate adenocarcinoma to neuroendocrine carcinoma lineage and the activation of KIT signaling pathway, and finds that KIT inhibitors have clinical application prospects in the treatment of neuroendocrine prostate cancer.
