Deficiency Deficiencies with riboflavin are rare; it usually will occur, though, with other nutrient deficiencies. Symptoms of riboflavin deficiency include: o cheilosis (cracking at the corners of the mouth) o alopecia (hair loss) o a purple-reddish-inflamed tongue, red and/or swollen mouth cavity o angular stomatitis o eczema and dermatitis o conjunctivitis (inflammation of the muscus and lining of the eye) o cornea vascularization o severe ophthalmia o peripheral nerve dysfunction.
Some predisposing conditions that may lead to a riboflavin deficiency including the inborn error of a deficiency of D-glucose-6-phosphate dehydrogenase. This inborn error does not allow the body to add a phosphate group onto the riboflavin molecule to produce FMN. Other conditions include beta-thalassemia and kidney dialysis. The use of chlorpromazine and antimalarials compete with absorption while hyperthyroidism drugs depress the flavokinase enzyme. Oral contraceptives (high estrogen) often elevate and deplete circulating riboflavin levels. Also, diabetes, malignancy, congestive heart failure, alcoholism, chronic stress, and trauma may cause a predisposition to a riboflavin deficiency.
Sources Animal origin-based foods like liver, eggs, and pork have the most readily available sources to be absorbed. Other rich sources include milk sources like 2% milk, yogurt, ice milk, and cottage cheese. Fruits, vegetables, and cereal grains are a minor contributor of this vitamin.